Mutations in ftsI confer resistance to beta-lactam antibiotics. PBP3 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the ftsI gene in Haemophilus influenzae. Parallel classification system added to the ARO for organization of RGI results: Drug Class, Resistance Mechanism, AMR Gene FamilyĪddition of extensive ontological terms describing phenotypic testing for antimicrobial resistance Removal of redundant intermediate terms relating resistance determinant to drug class, with improved overall classification by Drug Class and Resistance Mechanism New use of the participates_in and has_part relationships in place of formerly incorrect usage of the part_of relationship for association of resistance determinants with their mechanism of action.Įxtensive addition of confers_resistance_to_drug relationships for efflux complexesĭrug and mechanism category updates for the Resistance Gene IdentifierĪddition of bitscores to detection models, curation of chloramphenicol exporter proteins, ontology changes, JSON file format changes Use of the part_of relationship now follows canonical usage and is restricted to association of sub-units with their large multi-unit protein complexesĮxtensive revisions to the antimicrobial efflux branch of the AROĮxtensive revisions to the rRNA mutations branch of the ARO Expect significant changes in the ARO between monthly releases as well as occasional incomplete revisions, which may affect downstream analyses.

As such, the next two years will be a time of active development for the ARO. The Comprehensive Antibiotic Resistance Database gratefully acknowledges recent funding from the Genome Canada & Canadian Institutes of Health Research's Bioinformatics & Computational Biology program, allowing integration of the Antibiotic Resistance Ontology (ARO) with the Genomic Epidemiology Ontology, IRIDA platform, and OBO Foundry (see Genome Canada press release).

Pbp3 ftsi